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Apelin-13 TFA
Apelin-13 TFA 是 G 蛋白偶聯(lián)受體angiotensin II protein J (APJ) 的內(nèi)源性配體，ji活G蛋白偶聯(lián)受體的 EC50 值為 0.37 nM。Apelin-13 TFA 具有擴(kuò)張血管和降壓作用。Apelin-13 TFA 也可用于 2 型糖尿病及代謝綜合征的研究。
生物活性
Apelin-13 TFA is an endogenous ligand for the G-protein coupled receptor angiotensin II protein J (APJ), activating this G protein-coupled receptor with an EC50 value of 0.37 nM. Apelin-13 TFA has vasodilatory and antihypertensive effects. Apelin-13 TFA also can be used for researching type 2 diabetes and metabolic syndrome[1][2][3].
IC50 & Target
IC50: 0.37 nM (APJ)[1]
體內(nèi)研究(In Vivo)
Apelin-13 (200 μg/kg; IP, daily for 4 weeks) improves cardiac function, improves insulin resistance, improves lipid metabolism, significantly decreases TNF-α and leptin on serum, induces the expression of Apelin-12 in serum and markedly elevates GLUT4 and p-AMPKα2 levels[2].
Apelin-13 (10 and 100 μM; ICV, single dosage) increases the spontaneous discharges in the majority of pallidal neurons[4].
Animal Model:Goto-Kakizaki (GK) rats (12 weeks old; 240-280 g; fed with a high-fat diet: 66.5% standard chow, 10% lard, 20% sucrose, 2.5% cholesterol and 1% pig bile salt)[2]
Dosage:200 μg/kg
Administration:IP, daily for 4 weeks
Result:Significantly decreased heart rate; lowered the levels of fasting plasma glucose (FPG), fasting insulin (FINS) and homeostasis model assessment for insulin resistancey (HOMA-IR); decreased serum levels of total cholesterol (TC), triglyceride (TG) and low density lipoprotein-cholesterol (LDL-C) and increased high density lipoprotein-cholesterol (HDL-C); decreased NO level, cNOS activity, TNF-α and leptin in serum; induced the expression of Apelin-12.
分子量：1664.85
Formula：C71H112F3N23O18S
Sequence：Gln-Arg-Pro-Arg-Leu-Ser-His-Lys-Gly-Pro-Met-Pro-Phe
Sequence Shortening：QRPRLSHKGPMPF
運(yùn)輸條件：Room temperature in continental US; may vary elsewhere.
儲存方式：
Sealed storage, away from moisture
| Powder | -80°C | 2 years |
|---|---|---|
| -20°C | 1 year |
*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
溶解性數(shù)據(jù)
In Vitro:
H2O : 100 mg/mL (60.07 mM; Need ultrasonic)
| 濃度溶劑體積質(zhì)量 | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 0.6007 mL | 3.0033 mL | 6.0065 mL |
| 5 mM | 0.1201 mL | 0.6007 mL | 1.2013 mL |
| 10 mM | 0.0601 mL | 0.3003 mL | 0.6007 mL |
請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 儲存時，請在 6 個月內(nèi)使用，-20°C 儲存時，請在 1 個月內(nèi)使用。
Apelin-13 TFA
Apelin-13 TFA 是 G 蛋白偶聯(lián)受體angiotensin II protein J (APJ) 的內(nèi)源性配體，ji活G蛋白偶聯(lián)受體的 EC50 值為 0.37 nM。Apelin-13 TFA 具有擴(kuò)張血管和降壓作用。Apelin-13 TFA 也可用于 2 型糖尿病及代謝綜合征的研究。
生物活性
Apelin-13 TFA is an endogenous ligand for the G-protein coupled receptor angiotensin II protein J (APJ), activating this G protein-coupled receptor with an EC50 value of 0.37 nM. Apelin-13 TFA has vasodilatory and antihypertensive effects. Apelin-13 TFA also can be used for researching type 2 diabetes and metabolic syndrome[1][2][3].
IC50 & Target
IC50: 0.37 nM (APJ)[1]
體內(nèi)研究(In Vivo)
Apelin-13 (200 μg/kg; IP, daily for 4 weeks) improves cardiac function, improves insulin resistance, improves lipid metabolism, significantly decreases TNF-α and leptin on serum, induces the expression of Apelin-12 in serum and markedly elevates GLUT4 and p-AMPKα2 levels[2].
Apelin-13 (10 and 100 μM; ICV, single dosage) increases the spontaneous discharges in the majority of pallidal neurons[4].
Animal Model:Goto-Kakizaki (GK) rats (12 weeks old; 240-280 g; fed with a high-fat diet: 66.5% standard chow, 10% lard, 20% sucrose, 2.5% cholesterol and 1% pig bile salt)[2]
Dosage:200 μg/kg
Administration:IP, daily for 4 weeks
Result:Significantly decreased heart rate; lowered the levels of fasting plasma glucose (FPG), fasting insulin (FINS) and homeostasis model assessment for insulin resistancey (HOMA-IR); decreased serum levels of total cholesterol (TC), triglyceride (TG) and low density lipoprotein-cholesterol (LDL-C) and increased high density lipoprotein-cholesterol (HDL-C); decreased NO level, cNOS activity, TNF-α and leptin in serum; induced the expression of Apelin-12.
分子量：1664.85
Formula：C71H112F3N23O18S
Sequence：Gln-Arg-Pro-Arg-Leu-Ser-His-Lys-Gly-Pro-Met-Pro-Phe
Sequence Shortening：QRPRLSHKGPMPF
運(yùn)輸條件：Room temperature in continental US; may vary elsewhere.
儲存方式：
Sealed storage, away from moisture
| Powder | -80°C | 2 years |
|---|---|---|
| -20°C | 1 year |
*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
溶解性數(shù)據(jù)
In Vitro:
H2O : 100 mg/mL (60.07 mM; Need ultrasonic)
| 濃度溶劑體積質(zhì)量 | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 0.6007 mL | 3.0033 mL | 6.0065 mL |
| 5 mM | 0.1201 mL | 0.6007 mL | 1.2013 mL |
| 10 mM | 0.0601 mL | 0.3003 mL | 0.6007 mL |
請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 儲存時，請在 6 個月內(nèi)使用，-20°C 儲存時，請在 1 個月內(nèi)使用。
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