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Epibrassinolide (Synonyms: 表油菜素內酯; 24-Epibrassinolide; B1105; BP55)
Epibrassinolide (24-Epibrassinolide) 是一種廣泛存在的植物生長激素，具有緩解植物重金屬和農藥脅迫潛力。Epibrassinolide (24-Epibrassinolide) 在各種癌細胞中是一種潛在的凋亡誘導劑，而不影響非腫瘤細胞生長。
生物活性
Epibrassinolide (24-Epibrassinolide) is a ubiquitously occurring plant growth hormone which shows great potential to alleviate heavy metals and pesticide stress in plants[1]. Epibrassinolide is a potential apoptotic inducer in various cancer cells without affecting the non-tumor cell growth[2].
IC50 & Target
Plant growth regulator, Apoptosis inducer[1]
體外研究(In Vitro)
Epibrassinolide (EBR) is a biologically active compound of the brassinosteroids, steroid-derived plant growth regulator family. Cells are incubated with various doses (0-100 μM) of Epibrassinolide for 24 or 48 h and cell viability is determined by MTT assay. Epibrassinolide induced cell viability loss in dose- and time-dependent manner compared to untreated samples in LNCaP and DU145 prostate cancer cells. Increasing concentrations of Epibrassinolide is more effective on LNCaP cell viability loss than DU145 cells suggesting that androgen-dependent cells are more sensitive to Epibrassinolide than androgen-independent prostate cancer cells. In further experiments, 25 μM Epibrassinolide is selected due to its moderate cytotoxic effect on both cell lines. The effect of Epibrassinolide treatment is examined on cell proliferation by counting the cell number within 96 h. A higher and earlier inhibition of cell proliferation is observed in LNCaP than DU145 cells[1].
分子量：480.68
Formula：C28H48O6
CAS 號：78821-43-9
中文名稱：表油菜素內酯；布拉西諾內酯；歐洲油菜素
運輸條件：Room temperature in continental US; may vary elsewhere.
儲存方式：
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
溶解性數據
DMSO : 100 mg/mL (208.04 mM; Need ultrasonic)
| 濃度溶劑體積質量 | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.0804 mL | 10.4019 mL | 20.8039 mL |
| 5 mM | 0.4161 mL | 2.0804 mL | 4.1608 mL |
| 10 mM | 0.2080 mL | 1.0402 mL | 2.0804 mL |
請根據產品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復凍融造成的產品失效。
儲備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 儲存時，請在 6 個月內使用，-20°C 儲存時，請在 1 個月內使用。
參考文獻
Epibrassinolide (Synonyms: 表油菜素內酯; 24-Epibrassinolide; B1105; BP55)
Epibrassinolide (24-Epibrassinolide) 是一種廣泛存在的植物生長激素，具有緩解植物重金屬和農藥脅迫潛力。Epibrassinolide (24-Epibrassinolide) 在各種癌細胞中是一種潛在的凋亡誘導劑，而不影響非腫瘤細胞生長。
生物活性
Epibrassinolide (24-Epibrassinolide) is a ubiquitously occurring plant growth hormone which shows great potential to alleviate heavy metals and pesticide stress in plants[1]. Epibrassinolide is a potential apoptotic inducer in various cancer cells without affecting the non-tumor cell growth[2].
IC50 & Target
Plant growth regulator, Apoptosis inducer[1]
體外研究(In Vitro)
Epibrassinolide (EBR) is a biologically active compound of the brassinosteroids, steroid-derived plant growth regulator family. Cells are incubated with various doses (0-100 μM) of Epibrassinolide for 24 or 48 h and cell viability is determined by MTT assay. Epibrassinolide induced cell viability loss in dose- and time-dependent manner compared to untreated samples in LNCaP and DU145 prostate cancer cells. Increasing concentrations of Epibrassinolide is more effective on LNCaP cell viability loss than DU145 cells suggesting that androgen-dependent cells are more sensitive to Epibrassinolide than androgen-independent prostate cancer cells. In further experiments, 25 μM Epibrassinolide is selected due to its moderate cytotoxic effect on both cell lines. The effect of Epibrassinolide treatment is examined on cell proliferation by counting the cell number within 96 h. A higher and earlier inhibition of cell proliferation is observed in LNCaP than DU145 cells[1].
分子量：480.68
Formula：C28H48O6
CAS 號：78821-43-9
中文名稱：表油菜素內酯；布拉西諾內酯；歐洲油菜素
運輸條件：Room temperature in continental US; may vary elsewhere.
儲存方式：
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
溶解性數據
DMSO : 100 mg/mL (208.04 mM; Need ultrasonic)
| 濃度溶劑體積質量 | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.0804 mL | 10.4019 mL | 20.8039 mL |
| 5 mM | 0.4161 mL | 2.0804 mL | 4.1608 mL |
| 10 mM | 0.2080 mL | 1.0402 mL | 2.0804 mL |
請根據產品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復凍融造成的產品失效。
儲備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 儲存時，請在 6 個月內使用，-20°C 儲存時，請在 1 個月內使用。
參考文獻
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