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Metronidazole (Synonyms: 甲硝唑)
Metronidazole 是一種硝基咪唑類(lèi)抗生素，具有口服活性。Metronidazole 能夠穿過(guò)血腦屏障。Metronidazole 可用于厭氧微生物感染的研究。
生物活性
Metronidazole is an orally active nitroimidazole antibiotic. Metronidazole can cross blood brain barrier. Metronidazole can be used for the research of anaerobic infections[1][2][3][4].
體外研究(In Vitro)
Metronidazole displays inhibitory activity towards anaerobic protozoa Trichomonas vaginalis, Entamoeba histolytica, Giardia lamblia, and Balantidium coli[1].
Metronidazole (4-8 μg/mL) inhibits anaerobic bacteria and shows good bactericidal activity[1].
Metronidazole (0.1 μg/mL-0.01 mg/mL; 12-96 h) induces granular formation and triggers apoptosis in Blastocystis sp[2].
Apoptosis Analysis[2]
| Cell Line: | Blastocystis sp. Cells |
| Concentration: | 0.1 μg/mL-0.01 mg/mL |
| Incubation Time: | 12, 24, 48, 60, 72, 84, 96 hours |
| Result: | Decreased cell diameter, as a hallmark of an apoptotic cell, and resulted cell shrinkage. |
體內(nèi)研究(In Vivo)
Metronidazole (135 mg/kg/d; p.o.; 28 d) can cross the blood brain barrier, and exhibits neurotoxicity under long term administration in rats[3].
Metronidazole (1 g/L; p.o.; 4 weeks) results skeletal muscle atrophy and changes the expression of genes involved in the muscle peripheral circadian rhythm machinery and metabolic regulation[4].
| Animal Model: | Sprague-Dawley (SD) rats (200-220 g)[3] |
| Dosage: | 135 mg/kg |
| Administration: | Oral gavage; once daily; 28 days |
| Result: | Caused inflammatory markers increasing, including iNOS, eNOS, Bax and caspase 3 protein expressions increasing and caused oxidative stress damage in brain tissue, with MDA content rising. |
分子量：171.15
Formula：C6H9N3O3
CAS 號(hào)：443-48-1
中文名稱：甲硝唑
來(lái)源：Gram-negative and Gram-positive anaerobic
運(yùn)輸條件：Room temperature in continental US; may vary elsewhere.
儲(chǔ)存方式：
4°C, protect from light
*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
溶解性數(shù)據(jù)
DMSO : 35 mg/mL (204.50 mM; Need ultrasonic and warming)
H2O : 16.67 mg/mL (97.40 mM; Need ultrasonic)
| 濃度溶劑體積質(zhì)量 | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 5.8428 mL | 29.2141 mL | 58.4283 mL |
| 5 mM | 1.1686 mL | 5.8428 mL | 11.6857 mL |
| 10 mM | 0.5843 mL | 2.9214 mL | 5.8428 mL |
請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲(chǔ)備液；一旦配成溶液，請(qǐng)分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲(chǔ)備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C 儲(chǔ)存時(shí)，請(qǐng)?jiān)?6 個(gè)月內(nèi)使用，-20°C 儲(chǔ)存時(shí)，請(qǐng)?jiān)?1 個(gè)月內(nèi)使用。
以下溶解方案都請(qǐng)先按照 In Vitro 方式配制澄清的儲(chǔ)備液，再依次添加助溶劑：
——為保證實(shí)驗(yàn)結(jié)果的可靠性，澄清的儲(chǔ)備液可以根據(jù)儲(chǔ)存條件，適當(dāng)保存；體內(nèi)實(shí)驗(yàn)的工作液，建議您現(xiàn)用現(xiàn)配，當(dāng)天使用； 以下溶劑前顯示的百
分比是指該溶劑在您配制終溶液中的體積占比；如在配制過(guò)程中出現(xiàn)沉淀、析出現(xiàn)象，可以通過(guò)加熱和/或超聲的方式助溶
- 2.
請(qǐng)依序添加每種溶劑： 10% DMSO 90% (20% SBE-β-CD in saline)
Solubility: ≥ 2.08 mg/mL (12.15 mM); Clear solution
- 3.
參考文獻(xiàn)
Metronidazole (Synonyms: 甲硝唑)
Metronidazole 是一種硝基咪唑類(lèi)抗生素，具有口服活性。Metronidazole 能夠穿過(guò)血腦屏障。Metronidazole 可用于厭氧微生物感染的研究。
生物活性
Metronidazole is an orally active nitroimidazole antibiotic. Metronidazole can cross blood brain barrier. Metronidazole can be used for the research of anaerobic infections[1][2][3][4].
體外研究(In Vitro)
Metronidazole displays inhibitory activity towards anaerobic protozoa Trichomonas vaginalis, Entamoeba histolytica, Giardia lamblia, and Balantidium coli[1].
Metronidazole (4-8 μg/mL) inhibits anaerobic bacteria and shows good bactericidal activity[1].
Metronidazole (0.1 μg/mL-0.01 mg/mL; 12-96 h) induces granular formation and triggers apoptosis in Blastocystis sp[2].
Apoptosis Analysis[2]
| Cell Line: | Blastocystis sp. Cells |
| Concentration: | 0.1 μg/mL-0.01 mg/mL |
| Incubation Time: | 12, 24, 48, 60, 72, 84, 96 hours |
| Result: | Decreased cell diameter, as a hallmark of an apoptotic cell, and resulted cell shrinkage. |
體內(nèi)研究(In Vivo)
Metronidazole (135 mg/kg/d; p.o.; 28 d) can cross the blood brain barrier, and exhibits neurotoxicity under long term administration in rats[3].
Metronidazole (1 g/L; p.o.; 4 weeks) results skeletal muscle atrophy and changes the expression of genes involved in the muscle peripheral circadian rhythm machinery and metabolic regulation[4].
| Animal Model: | Sprague-Dawley (SD) rats (200-220 g)[3] |
| Dosage: | 135 mg/kg |
| Administration: | Oral gavage; once daily; 28 days |
| Result: | Caused inflammatory markers increasing, including iNOS, eNOS, Bax and caspase 3 protein expressions increasing and caused oxidative stress damage in brain tissue, with MDA content rising. |
分子量：171.15
Formula：C6H9N3O3
CAS 號(hào)：443-48-1
中文名稱：甲硝唑
來(lái)源：Gram-negative and Gram-positive anaerobic
運(yùn)輸條件：Room temperature in continental US; may vary elsewhere.
儲(chǔ)存方式：
4°C, protect from light
*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
溶解性數(shù)據(jù)
DMSO : 35 mg/mL (204.50 mM; Need ultrasonic and warming)
H2O : 16.67 mg/mL (97.40 mM; Need ultrasonic)
| 濃度溶劑體積質(zhì)量 | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 5.8428 mL | 29.2141 mL | 58.4283 mL |
| 5 mM | 1.1686 mL | 5.8428 mL | 11.6857 mL |
| 10 mM | 0.5843 mL | 2.9214 mL | 5.8428 mL |
請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲(chǔ)備液；一旦配成溶液，請(qǐng)分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲(chǔ)備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C 儲(chǔ)存時(shí)，請(qǐng)?jiān)?6 個(gè)月內(nèi)使用，-20°C 儲(chǔ)存時(shí)，請(qǐng)?jiān)?1 個(gè)月內(nèi)使用。
以下溶解方案都請(qǐng)先按照 In Vitro 方式配制澄清的儲(chǔ)備液，再依次添加助溶劑：
——為保證實(shí)驗(yàn)結(jié)果的可靠性，澄清的儲(chǔ)備液可以根據(jù)儲(chǔ)存條件，適當(dāng)保存；體內(nèi)實(shí)驗(yàn)的工作液，建議您現(xiàn)用現(xiàn)配，當(dāng)天使用； 以下溶劑前顯示的百
分比是指該溶劑在您配制終溶液中的體積占比；如在配制過(guò)程中出現(xiàn)沉淀、析出現(xiàn)象，可以通過(guò)加熱和/或超聲的方式助溶
- 2.
請(qǐng)依序添加每種溶劑： 10% DMSO 90% (20% SBE-β-CD in saline)
Solubility: ≥ 2.08 mg/mL (12.15 mM); Clear solution
- 3.
參考文獻(xiàn)
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